Yes. France's US State Department rating is Level 2 ("exercise
increased caution") — the same band as Italy, the UK, and Germany —
and the elevated level reflects generic European terrorism risk,
not anything specific to Lyon. Lyon is a working European
metropolis with the crime profile of any French city its size:
violent crime against travelers is rare, and the city center
feels visibly safer than equivalent neighborhoods in Marseille
or even some districts of Paris. The realistic risk is
opportunistic pickpocketing on the metro, in Place Bellecour, and
around Lyon Part-Dieu station at rush hour.
On a Passports teacher-led trip the group is never on public
transport alone, the Tour Director runs a pickpocket-awareness
briefing on the first evening, and every hotel is pre-vetted for
24-hour reception and secure room storage. We operate a 24/7
emergency line out of Boston, keep parents on a daily-update
channel, and have English-speaking medical contacts in every city
we visit. For most teachers running their first school group tours
to France, Lyon feels easier than Paris on the safety side and
every bit as rich on the curricular side.